Growth factors are the main regulators of growth, development and cell balance maintenance processes. Cellular consistency of rapidly renewing tissues (blood, epithelium), for example, depends on activation, proliferation and differentiation of tissue-specific stem cells and is regulated with different growth factors. As an example of growth factors, EGF (epidermal growth factor),FGF (fibroblast growth factor), PDGF (platelet derived growth factor), VEGF (vessel endothelial growth factor), IGF (insulin-like growth factor) and many others can be mentioned.

     Despite the fact that the name of these factors reflects the cellular lines this doesn't mean that their effect is restricted to this cell line. The most factors are universal. They affect many cell types, stimulating their proliferation and differentiation, or inhibit their activity. But almost every process in the body is controlled by their specific combination. Growth factors mediate the impact of one cell on others.

     Dermal fibroblasts that synthesize a number of GF can be an example of the cell's interaction with the other cell types of the skin. Basic FGF activates the vessel growth (angiogenesis), TGF-beta (transforming growth factor) defines chemotropism (the directed cells migration according to the chemical agent gradient concentration) of fibroblasts and, besides, the synthesize of intercellular compounds; KGF (keratinocyte growth factor) accelerates wounds regeneration; EGF (epithelial growth factor) activates proliferation and migration of keratinocytes (epidermal cells). Besides bFGF expression stimulates other cells of skin, it activates fibroblasts themselves. So growth factors regulate basic processes of regeneration and maintain the balance of all tissue compounds.

     All these notions of the growth factors biological role in processes of all skin elements made a ground to the research work of the Center of cells technologies of youth Beauty PLAZA to create the Youth activator. The Youth activator is a unique complex of biotechnological components, that is based on growth factors application that activates intrinsic fibroblasts. It is applicated locally in the areas that requires drastic rejuvenation. After its injections the native collagen increases, that normally occurs only in the young skin. The incremental synthesis of native collagen provides the biological youth of tissues and has long-lasting effect of face, neck, décolleté, arms and body rejuvenation.